| ABSTRACT: |
|
Several polyphenolic compounds were tested for the inhibition of lung
metastasis induced by B16F10 melanoma cells in mice. Oral administration
of polyphenols such as curcumin and catechin at concentrations of 200
nmol/kg body weight were found to inhibit the lung metastasis maximally as
seen by the reduction in the number of lung tumor nodules (80%). Other
polyphenols which inhibited the lung tumor nodule formation were rutin
(71.2%), epicatechin (61%), naringin (27.2%) and naringenin (26.1%). The
polyphenols which did not inhibit lung tumor nodule formation were
quercetin, morin and ellagic acid. Consequent to the inhibition of the
lung tumor nodules, the life span of animals treated with polyphenols was
also found to be increased. Curcumin (143.85%), catechin (80.81%) and
rutin (63.59%) had maximal increase in life span. The results indicate a
possible use of these compounds in arresting the metastatic growth of
tumor cells. |