| AUTHOR: | Wargovich MJ | |
| TITLE: | Experimental evidence for cancer preventive elements in foods. | |
| SOURCE: | Cancer Lett; 114(1-2):11-7 1997 UI: 97256404 | |
| ABSTRACT: | The last decade has witnessed an incredible advance in our understanding of how fruits and vegetables work to prevent cancer. Epidemiological studies have suggested that a diet rich in fruits and vegetables is associated with reduced risk for a number of common cancers. Food chemists and natural product scientists have identified hundreds of 'phytochemicals' that are being evaluated for the prevention of cancer. Food components can modify carcinogenesis in one of five different ways. They may: (1) modify carcinogen activation by inhibiting Phase 1 enzymes; (2) modify how carcinogens are detoxified through Phase 2 pathways; (3) scavenge DNA reactive agents; (4) suppress the abnormal proliferation of early, preneoplastic lesions; and (5) inhibit certain properties of the cancer cell. | |
| MESH TERMS: | ras Proteins/Antagonists and Inhib | |
| Animal | ||
| Calcium/Pharmacology | ||
| Carcinogens/*Antagonists and Inhib/*Metabolism | ||
| Carotenoids/Pharmacology | ||
| Cell Division/Drug Effects | ||
| Colonic Neoplasms/Prevention and Control | ||
| Curcumin/Pharmacology | ||
| Cytochrome P-450 CYP2E1/Antagonists and Inhib | ||
| Diet* | ||
| DNA Adducts/Metabolism | ||
| Ellagic Acid/Pharmacology | ||
| Esophageal Neoplasms/Prevention and Control | ||
| Fruit | ||
| Pancreatic Neoplasms/Prevention and Control | ||
| Reactive Oxygen Species | ||
| Skin Neoplasms/Prevention and Control | ||
| Support, Non-U.S. Gov't | ||
| Support, U.S. Gov't, P.H.S. | ||
| Tea | ||
| Terpenes/Pharmacology | ||
| Vegetables | ||
| Vitamin D/Pharmacology | ||
| LANGUAGE: | ENG | |
| PUBLICATION TYPE: | JOURNAL ARTICLE | |
| REVIEW | ||
| REVIEW, TUTORIAL | ||
| TITLE ABBREVIATION: | Cancer Lett | |
| YEAR: | 1997 |