AUTHOR:		Krishnan K, Brenner DE
TITLE:		Chemoprevention of colorectal cancer.
SOURCE:		Gastroenterol Clin North Am; 25(4):821-58 1996   UI: 97120224
ABSTRACT:		This review summarizes the principles of cancer chemoprevention and discusses the evidence from epidemiologic and experimental studies and preclinical and clinical trials of potential colorectal chemopreventive agents. The putative mechanisms of action of the drugs in chemoprevention and their potential to reduce the incidence and mortality rate of colorectal neoplasms are discussed. The future of colorectal chemoprevention will depend on important new insights into molecular carcinogenesis of colorectal cancer, application of molecular markers as surrogate endpoints, and ultimately on therapeutic targets of prevention in clinical trials.
MESH TERMS:		Animal
		Anti-Inflammatory Agents, Non-Steroidal/Therapeutic Use
		Anticarcinogenic Agents/*Therapeutic Use
		Antioxidants/Therapeutic Use
		Calcium/Therapeutic Use
		Colorectal Neoplasms/*Prevention and Control
		Eflornithine/Therapeutic Use
		Ellagic Acid/Therapeutic Use
		Human
		Pyrazines/Therapeutic Use
		Support, Non-U.S. Gov't
		Support, U.S. Gov't, Non-P.H.S.
		Support, U.S. Gov't, P.H.S.
LANGUAGE:		ENG
PUBLICATION TYPE:		JOURNAL ARTICLE
		REVIEW
		REVIEW, ACADEMIC
TITLE ABBREVIATION:		Gastroenterol Clin North Am
YEAR:		1996