TITLE:		[The protective action of ellagic acid in experimental myocarditis]
AUTHOR:		Iakovleva LV, Ivakhnenko AK, Buniatian ND
SOURCE:		Eksp Klin Farmakol; 61(3):32-4 1998   UI: 98354527
ABSTRACT:		The article presents the material on the study of the cardioprotective effect of ellagic acid on a model of neoepinephrine myocarditis in rats. In doses of 0.5-1 mg/kg ellagic acid causes a marked antioxidant effect. Restores the disturbed myocardial functions. The reference-agent vitamin E (50 mg/kg) yields to ellagic acid as a cardioprotector. The effect of 0.5 mg/kg of ellagic acid was more stable than that of a 1 mg/kg dose. The cardioprotective activity of the drugs under study was determined according to the POL parameters in a myocardial homogenate and blood serum and according to the EEG parameters and the degree of cardiomyocyte cytolysis.
LANGUAGE:		RUS
PUBLICATION TYPE:		JOURNAL ARTICLE
TITLE ABBREVIATION:		Eksp Klin Farmakol
YEAR:		1998
ADDRESS:		Central Research Laboratory, Ukranian Pharmaceutical Academy, Kharkov, Ukraine.