| SOURCE: |
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Non-serial; Cellular and Molecular Targets for Chemoprevention. Steele
VE, Stoner GD, Boone CW et al, eds. Boca Raton, FL, CRC, 373 p., 1992.:
1992 UI: 95606652 |
| ABSTRACT: |
|
This volume represents the proceedings of a workshop sponsored by the
National Cancer Institute on Cellular and Molecular Targets for
Chemoprevention, held in Charleston, South Carolina, March 16-19, 1991,
and involving 44 invited participants. The relatively slow pace of
advances in the therapy of the major life-threatening cancers has led to a
growing emphasis on possible preventive approaches to this group of
diseases. Chemoprevention, the use of chemical agents to prevent or
reverse early precancerous changes in cancer-susceptible populations, is
the most recent approach to cancer prevention and control. The contents of
this book are divided into two major sections. Under the area of cell
membrane modifications, the topics considered are the potential use of the
latent transforming growth factor betas, membrane lipids and signalling in
cell growth regulation, and the use of cell culture systems in mechanistic
studies of chemopreventive agents. The second section on nuclear targets
of chemoprevention is more extensive and wide ranging, extending in fact
beyond nuclear targets per se. The topic areas included are: human DNA
repair gene expression; application of oligonucleotide drugs; regulation
of proliferation and differentiation by retinoic acid; zinc finger domains
of proteins encoded by oncogenes in relation to cancer chemoprevention and
therapy; the role of tumor suppressor genes in human colorectal cancer;
ellagic acid and synthetic analogues as inhibitors of mutagenesis and
carcinogenesis; potential strategies of chemoprevention through modulation
of protein kinase C activity; free radicals as targets for
chemoprevention; chemical protection against cancer by induction of Phase
II enzymes; ornithine decarboxylase as a possible target; arachidonic acid
metabolism; inhibition of carcinogen-adduct formation; the role of
calcium; immunomodulation of carcinogenesis; and cell invasion as a
target. The book concludes with a general discussion by participants.
Chapters are well referenced and illustrated with figures and
tables. |