| SOURCE: |
|
Non-serial; Cancer Chemoprevention. Wattenberg L, Lipkin M, Boone WB,
et al, eds., Boca Raton, FL, CRC Press, 630 p., 1993.: 1993
UI: 95606775 |
| ABSTRACT: |
|
This volume represents the proceedings of the 'Workshop on Cancer
Chemoprevention,' held in La Jolla, California, on February 2-5, 1991. As
is stressed in the introduction to this book, cancer chemoprevention is a
highly interdisciplinary field in which relatively few scientists are
involved, so that there is a paucity of fundamental information and need
for more investigators, while testing with cancer development as the
endpoint is slow, laborious and expensive, both in animal models and
humans, so that reliable intermediate endpoints are urgently needed. The
workshop was intended to focus on these problems and their solution, as
well as to present the latest information. The contributions from 47
collaborators are grouped into 11 categories, beginning with four chapters
that represent overviews of the area. They cover environmental carcinogens
and anticarcinogens, chemoprevention by naturally occurring and synthetic
compounds, recent preclinical and clinical results from the National
Cancer Institute, and the histopathology of human intraepithelial
neoplasia. Succeeding sections cover: retinoids, from basic mechanisms to
clinical trials in breast, basal cell and lung cancer, and oral
leukoplakia; inhibitors of the arachidonic acid cascade and their
application to chemoprevention of colon and skin cancers; sulfur
compounds, including N-acetylcysteine, oltipraz, garlic compounds and
alkyl isothiocyanates; micronutrients; prevention of the formation of
carcinogens in foods by such compounds as ascorbic acid and tocopherol; a
variety of polyphenolics including ellagic acid, curcumin, and the green
tea polyphenolics; other promising chemopreventive agents, such as
dehydroepiandrosterone, selenium, glycyrrhetinic acid and protease
inhibitors; polyamine synthesis inhibitors such as
difluoromethylornithine; future possibilities in chemoprevention with
stress on genetic parameters; and considerations regarding development of
chemopreventive drugs, both the challenges for the future, and the results
obtained with the four current leading agents. There is an adequate
subject index, and the discussions that followed the presentations are
included. |