| SOURCE: |
|
Non-serial; Food and Cancer Prevention: Chemical and Biological
Aspects. Waldron KW, Johnson IT, Fenwick GR, eds. Cambridge, UK, Royal
Society of Chemistry, 461 p., 1993.: 1993 UI: 95616078 |
| ABSTRACT: |
|
Epidemiological studies have provided evidence that food and dietary
components influence the development of cancers. This book represents the
proceedings of a biennial conference, sponsored by the Food Chemistry
Group of the Royal Society of Chemistry, held in Norwich, UK, September
13-16, 1992, which focused on the impact of diet on the basic mechanisms
of cell proliferation and differentiation. There are 67 papers and eight
workshop reports organized into nine parts by topic areas. Part 1 deals
with the relationships between diet and cancer in human populations,
including the roles of food and dietary components in promotion and
prevention of cancer. The occurrence and significance of carcinogens in
foods is the theme of Part 2. Chapter topics include the genotoxic effects
of nitrosamines, dithiocarbamates, and isothiocyanates, as well as
modulation of the metabolism of imidazoquinolines, antimutagenic action of
carotenes, carbohydrates and plant phenolics. Part 3 covers free radical
reactions and antioxidant nutrients in the etiology of human cancer in
general, and specifically in relation to lutein, vitamin A and carotenes,
vitamin C, alpha-tocopherol, and glutathione S-transferase. Part 4 is
devoted to tumor initiation, the significance of endogenous
biotransformation enzymes and their modulation by diet. Topics covered
include modulation of 1,2-dimethyl hydrazine-induced rat colonic
carcinogenesis, the influence of dietary fat on microsomal metabolism, and
the influence of flavonoids, ellagic acid, rosemary extracts, quercetin,
and diallyl sulfide on carcinogen metabolism and activity. Part 5
discusses the role of diet in suppressing tumor development by modulating
cell proliferation. Three of these chapters deal with epidemiologic
studies the remainder are experimental studies of garlic components and
omega 3 fatty acids. Immune mechanisms are covered in Part 6, while Part 7
covers the role of dietary fiber. The latter includes the interaction with
bile acids, effect on pH, nitrite-binding properties, effect on intestinal
transferases and effect on epithelial proliferation. Part 8 presents
research techniques, ranging from methods to determine rates of cellular
proliferation to chemical isolation and assay of mutagens and protective
agents. There is a brief subject index. |