AUTHOR:		Narayanan BA, Geoffroy O, Willingham MC, Re GG, Nixon DW
TITLE:		p53/p21(WAF1/CIP1) expression and its possible role in G1 arrest and apoptosis in ellagic acid treated cancer cells.
SOURCE:		Cancer Lett; 136(2):215-21 1999   UI: 99281882
ABSTRACT:		Ellagic acid is a phenolic compound present in fruits and nuts including raspberries, strawberries and walnuts. It is known to inhibit certain carcinogen-induced cancers and may have other chemopreventive properties. The effects of ellagic acid on cell cycle events and apoptosis were studied in cervical carcinoma (CaSki) cells. We found that ellagic acid at a concentration of 10(-5) M induced G arrest within 48 h, inhibited overall cell growth and induced apoptosis in CaSki cells after 72 h of treatment. Activation of the cdk inhibitory protein p21 by ellagic acid suggests a role for ellagic acid in cell cycle regulation of cancer cells.
MESH TERMS:		Apoptosis*
		Blotting, Western
		Cell Division/Drug Effects
		Cyclins/*Biosynthesis
		Dose-Response Relationship, Drug
		DNA/Biosynthesis
		DNA Fragmentation
		Ellagic Acid/*Pharmacology
		Enzyme Inhibitors/*Metabolism
		Flow Cytometry
		G1 Phase/*Drug Effects
		Human
		Neoplasms/*Metabolism
		Protein p53/*Biosynthesis
		Time Factors
		Tumor Cells, Cultured
LANGUAGE:		ENG
PUBLICATION TYPE:		JOURNAL ARTICLE
TITLE ABBREVIATION:		Cancer Lett
YEAR:		1999